Runners seeking reliable support and responsive cushioning know the challenge of finding a shoe that balances stability without sacrificing comfort. Overpronation can lead to knee and ankle strain, while inadequate cushioning may compromise performance, especially over long distances. The Adrenaline running shoes from Brooks address these pain points head-on, combining targeted support and adaptive cushioning for a smoother, safer run.
Built around the innovative GuideRails Holistic Support System, these shoes gently correct excess motion, ideal for runners needing stability without overcorrection. With DNA LOFT v3 cushioning in newer models, they deliver a plush, lightweight ride that excels on extended runs. We evaluated dozens of user reviews, performance specs, and material upgrades across generations to identify the best models for every runner—whether you prioritize value, weather resistance, or premium comfort. Keep reading to find your perfect pair of adrenaline running shoes.
Best Options at a Glance

Brooks Women’s Adrenaline GTS 24
Best Value
- Supportive running
- DNA Loft v3
- GuideRails
- Engineered air mesh
- 12mm

Brooks Men’s Adrenaline GTS 23
Best Budget Friendly
- Supportive running
- Lightweight
- DNA LOFT v2
- Engineered air mesh
- Secure

Brooks Women’s Adrenaline GTS 22
Best Budget Women
- Supportive running
- 12mm
- DNA LOFT
- GuideRails
- Wide

Brooks Men’s Adrenaline GTS 23 GTX
Best All Weather
- Supportive running
- GORE-TEX Invisible Fit
- DNA LOFT v2
- GuideRails
- Engineered Air Mesh

Brooks Men’s Adrenaline GTS 24 Weatherized
Best Wet Traction
- DWR mesh
- DNA Loft v3
- GuideRails
- Wet/dry
- Reflective

Brooks Women’s Adrenaline GTS 25
Best Overall
- GuideRails” Holistic Support
- DNA LOFT v3
- Breathable engineered mesh
- 12mm
- APMA” Seal of Acceptance

Brooks Men’s Adrenaline GTS 24
Best Mid Range
- Supportive running
- DNA Loft v3
- GuideRails
- Engineered air mesh
- PDAC A5500

Brooks Men’s Adrenaline GTS 25
Best for Men
- Supportive running & walking
- Wide
- DNA LOFT v3
- GuideRails holistic
- Breathable engineered mesh
Adrenaline Running Shoes Review
Choosing the Right Adrenaline Running Shoe
Selecting the best Adrenaline running shoe depends on your individual needs and running style. Here’s a breakdown of key features to consider:
Support & Stability: GuideRails Technology
The core of the Adrenaline GTS line is the GuideRails Holistic Support System. This feature is crucial if you overpronate (your foot rolls inward excessively during your stride). GuideRails gently keep excess movement in check, aligning your body and reducing strain on your knees and ankles. Runners who need moderate stability will benefit most from this technology. If you have a neutral gait, you may not need this level of support and might find it restrictive. Consider how much support you actually need – too much can alter your natural stride, while too little leaves you vulnerable to injury.
Cushioning: DNA LOFT v3 vs. v2
Adrenaline shoes utilize Brooks’ DNA LOFT cushioning, with newer models featuring DNA LOFT v3. This is a key differentiator. DNA LOFT v3 is nitrogen-infused, making it significantly softer, lighter, and more responsive than previous versions (like v2 found in older models). More cushioning generally means more comfort, especially on longer runs, but can sometimes feel less “grounded.” DNA LOFT v2 is still comfortable, offering a good balance, and is often found in more budget-friendly options. Consider the distances you typically run – longer distances benefit from the enhanced cushioning of v3.
Fit & Upper Construction
The upper material significantly impacts comfort. Look for engineered mesh uppers, which provide a balance of breathability, stretch, and structure. Features like 3D Fit Print add structure without bulk. A secure, comfortable fit is paramount to avoid blisters and discomfort. Some models include a flat-knit collar for added flexibility. Pay attention to sizing recommendations – Brooks shoes sometimes run slightly small, and ordering a half-size up is often recommended.
Additional Features to Consider:
- Waterproofing (GTX Models): GORE-TEX Invisible Fit provides waterproof protection for running in wet conditions.
- Weatherized Options: DWR (durable water repellent) treated uppers and enhanced traction for all-weather running.
- Diabetic Friendly: Many Adrenaline models are certified PDAC A5500 Diabetic shoes.
- Outsole Design: Designed for smooth transitions and reliable traction.
- Reflectivity: Important for visibility during low-light runs.
Adrenaline Running Shoe Comparison
| Product | Best For | Cushioning Technology | Support System | Waterproof | Upper Material |
|---|---|---|---|---|---|
| Brooks Women’s Adrenaline GTS 25 | Best Overall | DNA LOFT v3 | GuideRails Holistic Support | No | Engineered Mesh |
| Brooks Men’s Adrenaline GTS 25 | Best for Men | DNA LOFT v3 | GuideRails Holistic Support | No | Engineered Mesh |
| Brooks Women’s Adrenaline GTS 24 | Best Value | DNA LOFT v3 | GuideRails Holistic Support | No | Engineered Air Mesh |
| Brooks Men’s Adrenaline GTS 24 | Best Mid Range | DNA LOFT v3 | GuideRails Holistic Support | No | Engineered Air Mesh |
| Brooks Men’s Adrenaline GTS 23 | Best Budget Friendly | DNA LOFT v2 | GuideRails Holistic Support | No | Engineered Air Mesh |
| Brooks Women’s Adrenaline GTS 22 | Best Budget Women | DNA LOFT | GuideRails Holistic Support | No | Engineered Mesh |
| Brooks Men’s Adrenaline GTS 23 GTX | Best All Weather | DNA LOFT v2 | GuideRails Holistic Support | GORE-TEX Invisible Fit | Engineered Air Mesh |
| Brooks Men’s Adrenaline GTS 24 Weatherized | Best Wet Traction | DNA LOFT v3 | GuideRails Holistic Support | DWR Mesh | Knit DWR Mesh |
How We Tested Adrenaline Running Shoes
Our evaluation of adrenaline running shoes centers on data-driven analysis and comparative testing, focusing on the features crucial to performance and comfort. We analyzed specifications across multiple generations of the Adrenaline GTS series, comparing DNA LOFT v3 versus v2 cushioning using published material properties and user reviews regarding impact absorption and energy return.
We examined data from biomechanical studies on pronation and the effectiveness of Brooks’ GuideRails Holistic Support System, correlating stability features with runner profiles (neutral, overpronation). Comparative analyses focused on upper construction (engineered mesh, 3D Fit Print) and their impact on breathability and fit, referencing user feedback on blister prevention and overall comfort.
While physical testing wasn’t conducted directly, we leveraged extensive user reviews from reputable running communities and retail sites, applying sentiment analysis to identify consistent trends in reported experiences relating to fit, durability, and performance. We also considered the impact of additional features like GORE-TEX waterproofing and outsole design, comparing their effectiveness in diverse running conditions as reported in independent reviews and testing data available from running shoe review websites. This holistic approach ensures a comprehensive assessment of each Adrenaline model.
FAQs
What is the difference between DNA LOFT v2 and v3 cushioning in Adrenaline running shoes?
DNA LOFT v3 is nitrogen-infused, making it softer, lighter, and more responsive than DNA LOFT v2. This results in increased comfort, especially for longer runs, while v2 still offers a good balance of cushioning and responsiveness. Choosing between the two depends on your preference and typical running distance.
Are Adrenaline GTS shoes suitable for neutral runners?
While the Adrenaline running shoes are designed for runners who overpronate, neutral runners may find them comfortable if they prefer a more supportive shoe. However, the GuideRails Holistic Support System could feel restrictive for those with a natural, neutral gait.
What are GuideRails Holistic Support System and why are they important?
GuideRails are a key feature of the Adrenaline GTS line, designed to gently control excess movement and align your body. They’re particularly beneficial for runners who overpronate, helping to reduce strain and prevent injuries.
Are Brooks Adrenaline shoes true to size?
Brooks shoes sometimes run slightly small. Many runners recommend ordering a half-size up to ensure a comfortable and secure fit. It’s always best to check the specific sizing recommendations for the model you are considering and read user reviews regarding fit.
Final Thoughts
Ultimately, the ideal Adrenaline running shoe is the one that best complements your unique running style and needs. Consider your pronation level, typical running distances, and preferred cushioning feel when making your decision.
With a variety of models available, from budget-friendly options to waterproof versions, there’s an Adrenaline shoe to enhance nearly any runner’s experience. Prioritize a comfortable, secure fit and don’t hesitate to leverage resources like user reviews to find your perfect pair.